This article needs additional citations for verification. While the therapy cannot undo the effects of a person’s first puberty, developing secondary sex characteristics associated with a different gender can female sex hormone some or all of the distress and discomfort associated with gender dysphoria, and can help the person to “pass” or be seen as the gender they identify with. Several contraindications to androgen therapy exist. An absolute medical contraindication is pregnancy.
Hormone therapy for transgender individuals has been shown in medical literature to be safe in adults, when supervised by a qualified medical professional. Increases the effect of some oral medicines for diabetes and can cause dangerously low blood sugar levels. Because of these interactions, it is advised that trans men make their healthcare providers aware of their hormone therapy, when this is relevant to their treatment for other medical issues. The terminal half-life of testosterone in blood is about 70 minutes, so it is necessary to have a continuous supply of the hormone for masculinization.